*Impurities refer to the presence of complexing proteins, inactive neurotoxin, flagellin and bacterial DNA contaminants.1
Reference: 1. Park JY, et al. Neurotoxin impurities: A Review of threats to Efficacy. Plast Reconstr Surg Glob Open. 2020;8(1):e2627

IS YOUR BOTULINUM TOXIN TREATMENT LOSING ITS EFFECT?

Youthful appearance but shorter treatment effects
0%
of 2,201 Botulinum Toxin A treatment users who have taken at least 3 treatments, have experienced a decline in treatment effects.^^
0%
of the aforementioned 1,509 users felt disappointed when they experienced decreasing/diminishing efficacy in their Botulinum Toxin A treatments.^^
† This does not represent the comment of consumers from the market survey. ^^ A consumer market study conducted on "Consumer Experience with Toxin Resistance" by Merz Aesthetics in partnership with Frost & Sullivan across 7 Asia Pacific countries (Australia, Hong Kong, India, Singapore, South Korea, Taiwan and Thailand) and included 2,201 Botulinum toxin users from the ages of 21 to 55 years old.
Trying different brand
0%
of the 1,509 users continued their Botulinum Toxin A treatments despite experiencing a decreasing/diminishing efficacy in their treatments.^^
0%
of the aforementioned 972 users who experienced a decline in treatment effects, switched to another brand of Botulinum Toxin A.^^
† This does not represent the comment of consumers from the market survey. ^^ A consumer market study conducted on "Consumer Experience with Toxin Resistance" by Merz Aesthetics in partnership with Frost & Sullivan across 7 Asia Pacific countries (Australia, Hong Kong, India, Singapore, South Korea, Taiwan and Thailand) and included 2,201 Botulinum toxin users from the ages of 21 to 55 years old.
Treatment losing effect over time
0%
of the 2,201 users are aware that antibody formation against Botulinum Toxins within our body is one of the key reasons for decreasing/diminishing or, no efficacy of Botulinum Toxin A treatments.^^
0%
of the 2,201 users are aware that the presence of impurities*, such as complexing proteins, may lead to antibody formation against Botulinum Toxin within our body.^^1,2
† This does not represent the comment of consumers from the market survey. ^^ A consumer market study conducted on "Consumer Experience with Toxin Resistance" by Merz Aesthetics in partnership with Frost & Sullivan across 7 Asia Pacific countries (Australia, Hong Kong, India, Singapore, South Korea, Taiwan and Thailand) and included 2,201 Botulinum toxin users from the ages of 21 to 55 years old.
Reference:
2. Kerscher M, et al. IncobotulinumtoxinA: A Highly Purified and Precisely Manufactured Botulinum Neurotoxin Type A. J Drugs Dermatol. 2019 Jan 1;18(1):52-57
0%
of the 2,201 users are willing to choose a Botulinum Toxin A product which has high purity that may lower the risk of antibody formation and thereby, the risk of decreasing/diminishing efficacy of Botulinum Toxin A treatments if they were informed earlier.^^
0%
of the 2,201 users are willing to recommend a Botulinum Toxin A product which has high purity that may lower the risk of antibody formation and thereby, the risk of diminishing efficacy of Botulinum Toxin A to others.^^
† This does not represent the comment of consumers from the market survey. ^^ A consumer market study conducted on "Consumer Experience with Toxin Resistance" by Merz Aesthetics in partnership with Frost & Sullivan across 7 Asia Pacific countries (Australia, Hong Kong, India, Singapore, South Korea, Taiwan and Thailand) and included 2,201 Botulinum toxin users from the ages of 21 to 55 years old.
 
Is your Botulinum Toxin treatment losing its effect?^

^This refers to 1) experiencing shorter durations of efficacy as compared to previous treatments,
2) treatment not producing the same desired outcome and / or
3) treatment becomes totally ineffective.

It could be due to Botulinum Toxin Resistance.

Definition: the ability of the body to neutralise the Botulinum Toxin product, which consequently results in little to no visible effect after multiple rounds of treatments.

This is caused by the development of neutralising antibodies against the active neurotoxin. The risk of developing resistance may be increased by the presence of impurities*.

WHAT ARE IMPURITIES* AND HOW THEY CAN AFFECT YOU

1 WHAT are impurities* in Botulinum Toxins?

Varying degrees of impurities* are found in most Botulinum Toxin A formulations due to differences in manufacturing and purification processes. These impurities* consist of complexing proteins, inactive neurotoxin, flagellin and bacterial DNA.

2 WHY are they harmful?

Impurities* in Botulinum Toxins increase the risk of activating the immune system, leading to the formation of neutralising antibodies (NABs) that diminish treatment efficacy over time or even cause complete non-response.

3 HOW can I prevent this?

It is important to choose a Pure Toxin with Zero Impurities* right from the start to ensure optimal results with every Botulinum Toxin treatment.

Introducing The PURE Toxin with Zero IMPURITIES*
ZERO IMPURITIES* = LOWER RISK OF NEUTRALISING ANTIBODY FORMATION

For all the benefits you can experience with Botulinum Toxin treatments, choose the Pure Toxin with Zero Impurities* as your lifetime aesthetic treatment that gives you the natural and lasting results you desire. Choose Zero Impurities*.
What DOES ZERO IMPURITIES* in PURE Toxin mean for you?
Z
Zero impurities* = Lower risk of neutralising antibody formation.
E
Efficacy is clinically proven.
R
Reduced risk of Botulinum Toxin resistance.
O
Optimal results with every treatment.
The Pure Toxin with Zero Complexing Proteins
Less
Resistance against Botulinum Toxin Chances of treatment failure
Zero
Complexing proteins Redundant components
More
Potent and Powerful
Take A Quiz How much do you know about Botulinum Toxin?
ASK THE EXPERTS
RESISTANCE IS REAL
Frequently Asked Questions

Q: What is Botulinum Toxin resistance?

A: Botulinum Toxin resistance is the formation of neutralising antibodies against Botulinum Toxin treatments, which results in reduced efficacy of subsequent treatments. The build-up of neutralising antibodies is due to the impurities* found in most Botulinum Toxin products. It is characterised by reduced to no treatment effect, or shortened treatment effect duration.

Q: What should I do if I’m experiencing Botulinum Toxin resistance?

A: As of now, there is no drug/medication to reverse Botulinum Toxin resistance. Start from the very beginning with the Pure Toxin with Zero Impurities* to minimise the risk. Consult a professional healthcare provider at a trusted aesthetic clinic or contact one here regarding the switch to Pure Toxin with Zero Impurities* for your next treatment.

Q: What are impurities*, and how does it affect me?

A: Impurities*such as complexing proteins form an unnecessary part of most Botulinum Toxin products. They are high molecular weight bacterial protein complexes that are bound to the active neurotoxins. The impurities* do not play a role in successful Botulinum Toxin treatment, in fact, it may cause neutralising antibodies to form, which can result in subsequent treatments to be rendered ineffective.

Q: How will Zero Impurities* make a difference for me?

A: Having zero impurities* lowers the risk of developing resistance towards Botulinum Toxin treatment, therefore maintaining the effectiveness of the treatment

Q: I’m concerned about looking plastic or fake after treatment. What should I do?

A: With the removal of impurities*, the Pure Toxin with Zero Impurities* have been proven to be clinically effective without the need for excessively high dosages. This provides a more natural look resulting from treatments. Looking plastic or overdone is a common concern among individuals considering an in-clinic treatment with Botulinum Toxin. If you share the same concerns, consult a licensed healthcare professional to discuss the treatment options available and about using the Pure Toxin with Zero Impurities*.

Q: How long does it take for the Pure Toxin with Zero Impurities* to take effect?

A: The initial effect will be visible within 3-4 days, with full effects kicking in within 30 days. The clinical effect of each treatment lasts up to 4 months on average, and repeated dosing of Pure Toxin with Zero Impurities* provides long term efficacy with minimal risk of developing Botulinum Toxin resistance.

Q: Will I experience any downtime when using the Pure Toxin with Zero Impurities*?

A: There is no expected downtime after treatment and you can return to any work or physical activity immediately. However, if you are experiencing any reactions to the treatment such as loss of strength, general muscle weakness, blurred vision or drooping eyelids, avoid operating any machinery or dangerous activities. If the effects persist or affect your day to day activities, consult your doctor immediately.

Q: How does the Pure Toxin with Zero Impurities* work?

A: The Pure Toxin with Zero Impurities* acts on nerve endings to block the release of a chemical that is needed for muscle contraction.
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