IS YOUR BOTULINUM TOXIN TREATMENT LOSING ITS EFFECT?

Youthful appearance but shorter treatment effects

of 2,201 Botulinum Toxin A treatment users who have taken at least 3 treatments, have experienced a decline in treatment effects.*

of the aforementioned 1,509 users felt disappointed when they experienced decreasing/diminishing efficacy in their Botulinum Toxin A treatments.*

of the 1,509 users continued their Botulinum Toxin A treatments despite experiencing a decreasing/diminishing efficacy in their treatments.*

of the aforementioned 972 users who experienced a decline in treatment effects, switched to another brand of Botulinum Toxin A.*

of the 2,201 users are aware that antibody formation against Botulinum Toxins within our body is one of the key reasons for decreasing/diminishing or, no efficacy of Botulinum Toxin A treatments.*

of the 2,201 users are aware that presence of complexing proteins in Botulinum Toxins may lead to antibody formation against Botulinum Toxins within our body.*^#

† This does not represent the comment of consumers from the market survey. * A consumer market study conducted on "Consumer Experience with Toxin Resistance" by Merz Aesthetics in partnership with Frost & Sullivan across 7 Asia Pacific countries (Australia, Hong Kong, India, Singapore, South Korea, Taiwan and Thailand) and included 2,201 Botulinum toxin users from the ages of 21 to 55 years old. # Stengel G, Bee EK. Antibody-induced secondary treatment failure in a patient treated with botulinum toxin type A for glabellar frown lines. Clin Interv Aging. 2011;6:281–4. # Torres S, et al. Neutralising antibodies to botulinum neurotoxin type A in aesthetic medicine: five case reports. Clin Cosmet Investig Dermatol. 2014;7:11-17

Botulinum Toxin with Zero Complexing Proteins

of the 2,201 users are willing to choose a Botulinum Toxin A product which has high purity (with zero complexing proteins) that may lower the risk of antibody formation and thereby, the risk of decreasing/diminishing efficacy of Botulinum Toxin A if they were informed earlier.*

of the 2,201 users are willing to recommend a Botulinum Toxin A product which has high purity (with zero complexing proteins) that may lower the risk of antibody formation and thereby, the risk of diminishing efficacy of Botulinum Toxin A to others.*

^ Dressler D. Five-year experience with incobotulinumtoxinA: the first botulinum toxin drug free of complexing proteins. Eur J Neurol 19:385–389 ‡ This does not include patients who have received botulinum toxins with complexing proteins in the past.

Is your Botulinum Toxin treatment losing its effect?^*

*This refers to 1) experiencing shorter durations of efficacy as compared to previous treatments,
2) treatment not producing the same desired outcome and / or
3) treatment becomes totally ineffective.

It could be due to Botulinum Toxin Resistance.

Definition: the ability of the body to neutralise the Botulinum Toxin product, which consequently results in little to no visible effect after multiple rounds of treatments.

This is caused by the development of neutralising antibodies against the active neurotoxin. The risk of developing resistance may be increased by the presence of complexing proteins.

Complexing Proteins and why it is unnecessary for you

#Stengel G, Bee EK. Antibody-induced secondary treatment failure in a patient treated with botulinum toxin type A for glabellar frown lines. Clin Interv Aging. 2011;6:281–4 #Torres S, et al. Neutralising antibodies to botulinum neurotoxin type A in aesthetic medicine: five case reports. Clin Cosmet Investig Dermatol. 2014;7:11-17

1 The Myth

Complexing proteins are foreign bacterial proteins found within most Botulinum Toxins, initially thought to stabilise the active neurotoxin and facilitate the uptake of Botulinum Toxins into target issues.

2 The Reality

Complexing proteins do not play an active role in treatment efficacy. However, the presence of complexing proteins may result in the formation of neutralising antibodies.^#

3 The Effect

The formation of neutralising antibodies may lead to treatment failure for avid user of Botulinum Toxin.^#

Take A Quiz How much do you know about Botulinum Toxin?

If my current Botulinum Toxin treatment is not working for me, I need to increase the dosage.

1/4

Botulinum Toxin resistance will not affect me as I’ve been using other Botulinum Toxin products for more than 3 years and it works.

2/4

Botulinum Toxin resistance can be reversed over time.

3/4

I can reduce the risk of developing Botulinum Toxin resistance by choosing the Pure Toxin with Zero Complexing Proteins.

4/4

Your Results

You got 0/4 right!
0/4 - [Answer]

Increasing dosage or frequency of injections is not the solution to your concern. Instead it may increase your chances of developing resistance.
It is not possible to predict when resistance to Botulinum Toxin will develop, but the risk increases with repeated treatments over time.
There is currently no drug/medication to reverse Botulinum Toxin resistance once it develops.
The Pure Toxin with Zero Complexing Proteins is your alternative to reduce the risk of resistance towards treatment.

Frequently Asked Questions

Q: What is Botulinum Toxin resistance?

A: Botulinum Toxin resistance is the formation of neutralising antibodies against Botulinum Toxin treatments, which results in reduced efficacy of subsequent treatments. The build-up of neutralising antibodies is due to the unnecessary complexing proteins found in most Botulinum Toxin products.

Q: What should I do if I’m experiencing Botulinum Toxin resistance?

A: As of now, there is no drug/medication to reverse Botulinum Toxin resistance. Start from the very beginning with the Pure Toxin with Zero Complexing Proteins to minimise the risk. Consult a professional healthcare provider at a trusted aesthetic clinic or contact one here regarding the switch to Pure Toxin with Zero Complexing Proteins for your next treatment.

Q: What are Complexing Proteins, and how does it affect me?

A: Complexing proteins form an unnecessary part of most Botulinum Toxin products. They are high molecular weight bacterial protein complexes that are bound to the active neurotoxins. The complexing proteins may cause neutralising antibodies to form, which can result in subsequent treatments to be rendered ineffective.

Q: How will Zero Complexing Proteins make a difference for me?

A: Having zero complexing proteins lowers the risk of developing resistance towards Botulinum Toxin treatment, therefore maintaining the effectiveness of the treatment.

Q: I’m concerned about looking plastic or fake after treatment. What should I do?

A: With the removal of complexing proteins, the Pure Toxin with Zero Complexing Proteins have been proven to be clinically effective without the need for excessively high dosages. This provides a more natural look resulting from treatments. Looking plastic or overdone is a common concern among individuals considering an in-clinic treatment with Botulinum Toxin. If you share the same concerns, consult a licensed healthcare professional to discuss the treatment options available and about using the Pure Toxin with Zero Complexing Proteins.

Q: How long does it take for the Pure Toxin with Zero Complexing Proteins to take effect?

A: The initial effect will be visible within 3-4 days, with full effects kicking in within 30 days. The clinical effect of each treatment lasts up to 4 months on average, and repeated dosing of Pure Toxin with Zero Complexing Proteins provides long term efficacy with minimal risk of developing Botulinum Toxin resistance.

Q: Will I experience any downtime when using the Pure Toxin with Zero Complexing Proteins?

A: There is no expected downtime after treatment and you can return to any work or physical activity immediately. However, if you are experiencing any reactions to the treatment such as loss of strength, general muscle weakness, blurred vision or drooping eyelids, avoid operating any machinery or dangerous activities. If the effects persist or affect your day to day activities, consult your doctor immediately.

Q: How does the Pure Toxin with Zero Complexing Proteins work?

A: The Pure Toxin with Zero Complexing Proteins acts on nerve endings in muscles to prevent the contraction of muscle fibres. This helps to relax the muscles, thereby removing dynamic frown lines. You will be able to see and feel the difference within 3 to 5 days after treatment.

IS YOUR BOTULINUM TOXIN TREATMENT LOSING ITS EFFECT?

Botulinum Toxin Resistance